Unusual Formation of Carbamate Salts: an Experimental Proof for the Mechanism of the Removal of Carbobenzoxy Group by Catalytic Hydrogenolysis
نویسنده
چکیده
Catalytic hydrogenolysis of Z-Gly-NH2 and Z-Ala-NH2 resulted in the corresponding free amides and carbamate salts. This observation is a further experimental proof that carbamic acid derivatives are intermediates of hydrogenolytic removal of carbobenzoxy group under neutral conditions. The ratio of the formation of the two compounds is dependent on the solvent, concentration and chemical structure. The carbamate salts can be acylated without difficulties under the conditions of peptide bond formation.
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